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However, it remains unclear whether cigarette smoking and alcohol drinking increase the risk of brain cancer.Results from observational studies on the relationship between cigarette smoking, alcohol intake, and risk of glioma, the most common brain malignancy, have been inconsistent, with results differing largely by study design (Mandelzweig et al, 2009; Galeone et al, 2013). Although prospective studies avoid potential biases associated with differential selection and recall between cases and controls and the reliance on proxy respondents, to date, few prospective studies have examined cigarette smoking and alcohol intake in relation to glioma risk (Mills et al, 1989; Efird et al, 2004; Silvera et al, 2006; Holick et al, 2007; Benson et al, 2008; Baglietto et al, 2011), and some were relatively small ( cases; Mills et al, 1989; Baglietto et al, 2011). Only two prospective studies have investigated risk in relation to beer, wine, and liquor intake with conflicting results; thus, it remains unclear whether consumption of particular types of alcohol influence glioma risk (Efird et al, 2004; Baglietto et al, 2011).We investigated the relationship between cigarette smoking, alcohol intake, and glioma risk in the National Institutes of Health AARP (formally known as the American Association of Retired Persons, NIH AARP) Diet and Health Study, a large prospective cohort study with detailed information on cigarette smoking behaviours (smoking status, intensity, and years since quitting) and alcohol drinking (type and level of intake) for more than 450 men and women.Top of pageMaterial and methodsBackground: Methods: Results: Conclusion: Material and methods Results Discussion Conflict of interest References Acknowledgements Figures and TablesStudy populationData collection for the NIH AARP study was initiated between 1995 and 1996 when questionnaires were mailed to AARP members between the ages of 50 and 71 years who resided in the states of California, Florida, Louisiana, Pennsylvania, New Jersey, and North Carolina and the metropolitan areas of Atlanta, Georgia, and Detroit, Michigan (Schatzkin et al, 2001).http://www.cheapjerseyschinapop.com